The process of the arrival of the life-saving drugs from the laboratory to the factory has always remained a mystery. Here all the credit goes to a process known as bioprocessing. It is often considered a secret that metamorphoses the tiny microorganisms into valuable medicines. Bioprocessing stands for the manufacturing of biological products with the incorporation of living organisms.
Today, when the rate of the diseases is increasing at a breakneck pace, it has become absolutely necessary to rely on the life-saving medicines that can alleviate the maladies to a certain extent. Here in this blog, we are going to delve into the scaling up of the bioprocessing techniques for conducting the industrial biomanufacturing process successfully.
Understanding the Idea of Bioprocessing
Bioprocessing has made its appearance in the commercial sphere as a wonder, and at the same time, it is in reality a critical aspect of biotechnology that takes part in encompassing a wide range of techniques. This process refers to the strategic usage of the living cells to create the products that are extremely beneficial for society as a whole.
As this particular component has its closest association with the welfare of society, it has become extremely significant to scale up the bioprocessing techniques. The World Manufacturing Forum 2024 here plays an integral role in exploring the new trends and techniques in the sphere of biomanufacturing. On the other hand, this thoughtfully designed session discussion is aimed at shedding light on the latest techniques that are optimising the scaling up of bioprocessing. Let’s begin with the below pointers to trace out the future possibilities associated with bioprocessing and biomanufacturing.
Significance of scaling up Bioprocessing for industrial biomanufacturing
The journey from lab to factory, scaling up the bioprocessing, is one of the most pivotal steps. And this quest clearly aids in ensuring that the biotechnological advancements are mitigating standards of the market and fulfilling the dynamic commercial needs. As per the existing statistical data, the size of the bioprocessing market is expected to reach $15.5bn USD by 2035. Here are the reasons for which scaling up of bioprocessing is a dire need for varied industries.
A) Optimisation of the products
Scaling up the process has the potential of accelerating the production system as a whole, and at the same time, it averts the chances of the wastage of the resources. In addition to that, in the phase of scaling up, different agents like temperature and others are strategically amalgamated with the lofty purpose of coming up with the maximum outputs.
B) Quality assurance
Secondly, when it comes to biomanufacturing, it becomes absolutely vital to upkeep the top-notch quality, and during the scaling up, a rigorous testing session is conducted to keep the chances of contamination away.
C) Commercialisation of biotechnological innovations
To bring the innovative breakthroughs from the laboratory to the marketplace, all you need to do is scale up the production of bioprocessing. The bioprocessing summit of global scale in the present context is enabling the researchers to come up with the biopharmaceutical products, enzymes, and other items that fit with the market demands. So, the scaling-up process is essential, as without it, it will never be possible to connect with the macroscale or to reach the consumers at the broader scale.
Techniques of scaling up bioprocessing for industrial biomanufacturing
Bioprocessing takes into account varied techniques that aid in producing the desired effects in the industrial standard. However, here are three major techniques that the researchers follow while delivering the outputs via bioprocessing.
1) Upstream processing
Upstream processing is one of the most prominent techniques that involves key steps like strategic selection of the microorganisms, development of media, inoculation, fermentation, and monitoring of the parameters.
2) Stage of purification
The purification procedure is all about the separation of the targeted products from the mixture of complex nature, and it takes into account techniques such as filtration, chromatography, and centrifugation.
3) Downstream processing
Last on the list, downstream processing also follows several techniques that lead to effective biomanufacturing for industrial purposes. The prominent techniques include formulation, packaging, and distribution.
Case Study
Amgen, driven by its goal of manufacturing monoclonal antibody drugs, has made the best use of the bioprocessing and facilitated its entry into the marketplace from the laboratory. This process has entailed techniques like perfusion-based cell culture, chromatography, and multi-column systems.
FAQs
1) What is the Bioprocessing Summit?
The Biomanufacturing Summit is a premier event that invites industry leaders to join and take part in the thought-provoking discussion regarding the best practices in bioprocessing and the latest trends and technologies.
2) What techniques are commonly used in bioprocessing?
Prevalent techniques in bioprocessing are fermentation, purification, chromatography, filtration, and crystallization. These techniques aid in producing and isolating the desired products from biological systems.
3) What are the advantages of bioprocessing?
Benefits of bioprocessing include sustainability, cost-effectiveness, high product quality, and the ability to produce complex biological products that are difficult to synthesise chemically.
Wrapping up
Scaling up bioprocessing techniques for industrial biomanufacturing is a crucial endeavour that bridges the void between laboratory research and commercial production. To gain in-depth insights regarding bioprocessing and its scaling up, it’s the most significant thing to join ‘World Manufacturing Forum, 2024’. To join this event, reach out to the Leadvent Group today.
